Bio-Rad extends range of anti-biotherapeutic antibodies to accelerate antibody drug development

Published: 25-Jun-2024

Supporting bioanalytical assay development for preclinical research and clinical trials

Bio-Rad Extends Range of Anti-Biotherapeutic Antibodies to Accelerate Antibody Drug Development

Four new anti-idiotypic antibodies and a new anti-MMAE antibody range support bioanalytical assay development for preclinical research and clinical trials

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIO.B), a global leader in life science research and clinical diagnostics products, today launched four new anti-idiotypic antibodies to the following drugs: atezolizumab (Tecentriq), avelumab (Bavencio), obinutuzumab (Gazyvaro), and ocrelizumab (Ocrevus), extending its range of anti-biotherapeutic antibodies. The company also introduced its anti-monomethyl auristatin E (MMAE) biotherapeutic antibody range for bioanalysis.

Bio-Rad’s range of ready-made anti-biotherapeutic antibodies enables the development of robust and reliable bioanalytical assays against marketed biologic drugs. The new anti-idiotypic antibodies are suitable for pharmacokinetic (PK) and antidrug-antibody assays for atezolizumab, avelumab, obinutuzumab, and ocrelizumab, enabling therapeutic drug monitoring for innovator and biosimilar products.

The anti-MMAE antibody range supports bioanalysis of antibody-drug conjugates (ADCs) carrying MMAE as payload. MMAE is a potent antimitotic agent that inhibits cell division. Due to its toxicity, MMAE is not used as a drug itself, but instead forms the payload component of ADCs. Bio-Rad’s new anti-MMAE biotherapeutic antibodies enable the development of sensitive assays for both ADCs incorporating the toxin, or the toxin itself.

“Bio-Rad’s extensive range of anti-biotherapeutic antibodies offers an effective solution to drug-specific bioanalytical assay development, enabling design of selective, sensitive, and reliable PK and ADA assays,” said John Cardone, Marketing Manager, Life Science Group, Bio-Rad. “Introduction of the new drug-specific and MMAE anti-biotherapeutic antibodies further expands the utility of our market-leading portfolio of over 200 anti-idiotypic antibodies, providing our customers with new and innovative bioanalysis tools to accelerate antibody drug discovery.”

To learn more about Bio-Rad’s anti-idiotypic antibodies, visit bio-rad.com/biotherapeutic-antibodies.

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