Nuvia Q joins Bio-Rad ion exchange media

Offers high productivity

Bio-Rad Laboratories, headquartered in Hercules, California, US, has introduced Nuvia Q ultra-high capacity anion exchange media, which meet the robustness, high productivity, and selectivity demanded by downstream processes.

Nuvia Q exhibits a dynamic binding capacity of greater than 170mg/ml at a flow rate of 300cm/hr, approximately tripling the binding capacity of first generation Sepharose Fast Flow media, the firm says. By maintaining high binding capacity even at fast flow rates, Nuvia Q can significantly improve productivity, while reducing cycle time for downstream biotherapeutics purification.

‘With downstream processing representing a significant amount of all manufacturing costs, the introduction of Nuvia Q addresses the need for robust, high-capacity process chromatography media that can consistently purify large volumes of drugs used in therapeutics,’ says Randy Jacinto, senior product manager in Bio-Rad’s Process Chromatography Division.

Nuvia Q targets the purification of monoclonal antibodies, recombinant proteins and vaccines. This anion exchange media, when used for the intermediate polishing of monoclonal antibodies, demonstrates high selectivity in the clearance of common contaminants in the feed stream such as dsDNA and host cell proteins.

Bio-Rad says the key benefits of the Nuvia Q anion exchange media are:

  • High binding capacity;
  • Excellent flow properties, producing faster flow rates without compromising dynamic binding capacity, allowing scientists to operate at higher linear velocities;
  • Strong selectivity;
  • High recovery and base stability.

Nuvia Q is built on the UNOsphere base matrix with proprietary surface extender technology. Surface modifications of the UNOsphere epoxide provide significantly higher binding capacities while maintaining fast flow rates.

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