ProBioGen and DIOSynVax partner to manufacture multivalent vaccine for hemorrhagic fever

Published: 28-Mar-2024

The novel vaccine targets HF diseases caused by Ebola, Marburg, and Lassa viruses

ProBioGen, a global Contract Development & Manufacturing Organisation (CDMO), has recently announced a partnership with DIOSynVax Ltd to manufacture DIOS-HFVac3, a trivalent hemorrhagic fever (HF) vaccine that was developed in collaboration with Prof. Wagners team (Molecular Virology, Institute of Medical Microbiology and Hygiene, University of Regensburg).

The novel vaccine targets HF diseases caused by Ebola, Marburg, and Lassa viruses. Epidemics of viral hemorrhagic fevers are a major public health concern and a major economic burden.

The increase of simultaneous epidemics in low and middle-income African regions stresses the urgency of a multivalent vaccine produced on a production platform resilient against supply limitations.

The pre-clinical efficacy of the novel trivalent vaccine has been demonstrated in challenge studies in animal models. ProBioGen’s MVA CR19 vector will be used to deliver the three HF vaccine antigens.

DIOS-HFVac3 will be manufactured on ProBioGen's cutting-edge industrial platform, which was developed for the production of a broad range of viral vaccines. The platform consists of the company’s proprietary AGE1.CR.pIX suspension cell line, proprietary chemically defined media and advanced scalable production and purification process.

Under the terms of the agreement, ProBioGen will conduct process and analytical development followed by manufacturing of DIOS-HFVac3 for clinical trials and subsequent regulatory approval.

"Our collaboration with DIOSynVax represents a significant milestone in ProBioGen's journey," said Dr Volker Sandig, Chief Scientific Officer at ProBioGen. "Our platform for the manufacturing of DIOS-HFVac3 underscores our commitment to advancing robust and resilient biopharmaceutical solutions for global health challenges, independent of the geographic region where these challenges may occur."

This research is funded by the Department of Health and Social Care as part of the UK Vaccine Network (UKVN), a UK Aid program to develop vaccines for diseases with epidemic potential in low and middle-income countries (LMICs).

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