Batavia Biosciences receives $8 million grant to develop rotavirus vaccine

Published: 22-Sep-2016

Will develop a low-cost manufacturing process using novel technologies in partnership with Bio Farma

Leiden, Netherlands-headquartered Batavia Biosciences has received an $8 million grant from the Bill & Melinda Gates Foundation to develop a low cost manufacturing process to develop an affordable rotavirus vaccine.

Rotavirus infection, associated with severe vomiting and diarrhoea, causes 215,000 child deaths globally, according to the World Health Organization.

Current marketed vaccines often demonstrate reduced efficacy in lower-income settings, have undesirable presentation characteristics and are too expensive for widespread use in developing countries, which means many millions of children remain at risk.

Chris Yallop, CSO of Batavia Biosciences, said to deliver a low cost manufacturing process that is suitable for developing countries, Batavia Biosciences will employ novel technologies such as fixed-bed, high cell density bioreactors.

Additionally, the vaccine will be based on the RV3-BB rotavirus strain, a naturally occurring attenuated strain developed by the Murdoch Children’s Research Institute that shows promising immunogenicity data in early testing.

Batavia Biosciences will develop the process in partnership with Indonesian vaccine manufacturer Bio Farma, which will be responsible for market authorisation and commercial manufacture.

Menzo Havenga, CEO of Batavia Biosciences, said: 'We are proud to work with the Bill & Melinda Gates Foundation and Bio Farma on bringing a safe, efficacious and affordable rotavirus vaccine to all in need as this vaccine is clearly long overdue.'

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