GSK has chosen Emma Walmsley, currently head of its Consumer Healthcare division, as its new Chief Executive.
She will succeed Andrew Witty, when he retires on 31 March 2017, and will join the GSK Board of Directors on 1 January 2017.
Walmsley joined GSK in 2010 from cosmetics giant L'Oréal after a 17-year career, during which she held a variety of marketing and general management roles in the UK, Europe and US.
From 2007 she was based in Shanghai as General Manager, Consumer Products for L'Oréal China.
GSK Consumer Healthcare was established in 2015 following the completion of GSK's three-part transaction with Novartis.
GSK Chairman Philip Hampton said Walmsley had been chosen after 'a very thorough and rigorous global selection process'.
Walmsley said she was 'delighted and honoured to be appointed GSK's next CEO'.
'I'm looking forward to working with Andrew and other leaders over the next few months to ensure a smooth handover and to develop plans for 2017 and beyond,' she said.
Hampton added: 'Under Andrew's leadership, GSK has successfully developed into a company with market-leading positions in pharmaceuticals, vaccines and consumer healthcare.
'These provide excellent platforms for sustainable, long-term growth, and we are confident Emma will successfully build on these strengths.'