There are many considerations when selecting a coating technology for user-friendly solid oral dosage forms. Dr Detlev Haack, Head of R&D, and Dr Martin Koeberle, Senior Manager Analytical Development, Hermes Pharma, consider the main issues.
The simple and effective delivery of an active pharmaceutical ingredient (API) is an important factor influencing treatment efficacy, tolerability and patient compliance. For this reason, many APIs are administered orally, either in a solid or liquid form.
To further improve the user-friendliness and acceptance of solid oral dosage forms, orally disintegrating granules that start dissolving in the mouth are becoming more common. As they are extremely easy to ingest, they have proven especially popular with patients requiring regular doses or those that find it difficult to swallow solid tablets, such as children, the elderly or individuals suffering from esophagitis.
However, for this method to prove effective, most APIs must be effectively coated using one of a variety of methods, the choice of which affects formulation time and cost, while also influencing drug efficacy.
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