Biotage launches integrated mass directed flash system

Reduces the number of steps required to purify and confirm a target compound

The Isolera Dalton system integrates a miniaturised mass detector and an advanced flash chromatography system into one platform

Biotage, a global supplier of solutions and technology for analytical, medicinal and peptide chemistry, has launched an automated, miniaturised mass directed flash purification system. The Isolera Dalton system integrates a miniaturised mass detector and an advanced flash chromatography system into one platform, which the Sweden-headquartered company says is a first.

The mass detector and Isolera Spektra flash purification system are integrated through the Isolera Dalton Nanolink unit, an intelligent sampling device which handles all fluids and synching calculations between the two units.

The Isolera Dalton fits inside a standard fume hood, requires no external pumps and is capable of both normal and reverse-phase separations, according to the company.

Compounds are identified in real time during purification and this informs the flash fractionation process, enabling the correct product to be collected by the system. The system automatically accommodates different column sizes and flow rates, overcoming issues with simple splitter-based systems.

‘Isolera Dalton significantly reduces the number of steps required to purify and confirm a target compound, thus improving workflow and increasing confidence that chemists have synthesized what was intended. Quite frankly there is nothing else like it on the market today or that even comes close,’ says Sunil Rana, Global Product Manager, Biotage.

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