These models allow companies to assess therapeutic effectiveness in nasal, airway (bronchial), and deep lung (alveolar) epithelia against members of the Coronaviridae family. The work will help to derisk development programmes and screen drugs for therapeutic effectiveness to accelerate development prior to clinical trials.
“This new model allows companies to screen compounds and formulations to answer critical questions about effectiveness against viral infections in the Coronaviridae family prior to the clinic”, commented Dr Jon Lenn, MedPharm’s Chief Technology Officer. “Finding effective new treatments quickly for these viral infections is imperative in these extraordinary times.”
MedPharm’s facility in North Carolina, US has a dedicated innovation laboratory, able to rapidly support the development of new types of in vitro pharmacodynamic/infection models.
The dedicated microbiology lab has been specifically designed with negative internal pressure and biological safety cabinets suitable for BSL2 work. These models are based on air liquid interface tissue culture of primary human cells from different regions of the respiratory system which are then infected with relevant corona viral strains.
MedPharm has a history of innovation in developing living tissue models to screen compounds and formulations. This experience allows MedPharm to quickly react and help solve project-specific problems for its customers and stay at the forefront of the latest scientific breakthroughs and technology.
Dr Jon Volmer, MedPharm’s Senior Director of Research Biology and Innovation, who has more than 15 years of experience in investigating of lung and respiratory disease at the University of North Carolina and the University of Texas, added: “We are looking forward to applying such a useful high throughput model to the development of new therapies for current and future coronaviruses.”
