New sample preparation system improves proteomics research productivity

Published: 16-Jun-2022

Thermo Scientific AccelerOme Automated Sample Preparation Platform brings greater reproducibility and standardisation to LC-MS workflows

Thermo Fisher Scientific Inc., the world leader in serving science, is helping proteomics researchers increase productivity and free up time for more value-added activities when generating high quality samples for analysis, using a new automated sample preparation system that integrates within any LC-MS workflow.

The Thermo Scientific AccelerOme Automated Sample Preparation Platform eliminates the need for labor-intensive, manual sample preparation for LC-MS analysis, including the associated method development and reagent sourcing. This allows users to focus on higher value tasks. Automated sample preparation also overcomes the challenge of maintaining reproducibility with manual methodologies, and the new platform’s pre-built validated methods and kit format reagents reduce further any risk of user error. The resulting peptide samples are of consistent high-quality. A novel built-in UV measurement of final peptide concentration prior to LC-MS analysis allows the standardisation of sample peptide input for LC-MS analysis, another metric that adds to the quality, reliability and robustness of the final experimental result. The platform supports the use of peptide standards to monitor LC-MS system performance, enabling instrument health monitoring during acquisition or through post-acquisition data analysis.

Thermo Fisher Scientific is showcasing the AccelerOme Automated Sample Preparation Platform during the 70th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, being held June 5-9, 2022 in Booth 400 at the Minneapolis Convention Center, Minneapolis, Minnesota and at the Hilton Minneapolis Grand Ballrooms E, F, G.

“Proteomics researchers in academia and biopharma face an array of challenges, especially demands for speed and productivity,” said Andreas Huhmer, senior marketing director, omics research, life sciences mass spectrometry, Thermo Fisher Scientific. “Appropriate automated sample preparation systems for LC-MS have a crucial role. They provide support for core facilities, where flexibility and reproducibility are essential. In research labs, sample preparation systems are necessary to help to automate complex samples and large sample sets in order to rapidly generate rigorous data for publication, and in biopharma, these systems offer speed and productivity in commercialisation. The AccelerOme platform provides a solution for proteomics LC-MS workflows.”

The AccelerOme sample preparation platform, designed with a unique experimental design tool, combines reliable and reproducible hardware with easy-to-use software and commercially available reagent kits for both label-free and TMT multiplexing applications. A software wizard guides users through each step, facilitating proteomics research to newcomers to the field. The new platform is optimised to fit into the Thermo Scientific Orbitrap MS ecosystem. End-to-end software, sample and study factor information are transferred from sample input all the way through to LC-MS acquisition through data analysis with Thermo Scientific Proteome Discoverer Software.

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