New solutions from Bosch Packaging Technology

Published: 20-Mar-2018

At Achema 2018, Bosch Packaging Technology presents its R&D, line and service competence, complemented by comprehensive Industry 4.0 solutions

At Achema, visitors will be able to experience the wide range of solutions that Bosch Packaging Technology offers.

“Divided into the pharma liquid and pharma solid world, we will show market novelties and portfolio expansions, digital solutions and services, which together result in optimally harmonised systems for all our customers' production processes,” said Uwe Harbauer, head of the pharma business unit at Bosch Packaging Technology.

In the liquid world, visitors can witness a market debut: a preparation system combined with a filling machine for sterile injection solutions. Thanks to synchronised components, the integrated solution provides an efficient design phase. It can then be realised and qualified quickly and easily in line with the Bosch line competence. Customers profit from reduced efforts, high time savings and a shorter time-to-market.

The new process system SVP250 LF for the production of injection solutions was developed by the Bosch subsidiary Pharmatec.

The conical shape of the process containers allows a broad production range of 15–250 litres and minimises product loss. For product transfer from the preparation system to the ALF 5000 filling and closing machine, Bosch showcases preconfigured versions for different product characteristics, such as clear solutions or suspensions.

Data exchange via the control panels, enables the process and filling systems to communicate with eachother.

Bosch further demonstrates the especially safe biopharmaceutical processing with a customised MHD system for aseptic filling. While 100% in-process control provides for high quality, the system offers the highest flexibility regarding packaging types such as pre-sterilised vials and syringes thanks to the use of robotic technology in the isolator – and is equipped for further packaging types and changing processes.

Amongst other inspection technologies, the AIM 3 is showcased for the safe testing of glass containers. With a small footprint, the machine combines cosmetic and particle inspection as well as high-voltage leak detection of the smallest cracks in the glass.

Defective containers are already sorted out during pre-inspection to prevent glass breakage in the inspection process. The automatic re-inspection makes sure that only defective products and containers are sorted out, thus reducing the false reject rate.

The semi-automated MSA assembly machine from the Bosch subsidiary Moeller & Devicon will also be on display.

Suited for the efficient assembly of multi-piece disposable pens or auto-injectors, underlining the competence in cartridge and syringe processing. The modular and scalable platform accounts for the trend towards smaller batch sizes. Thanks to standardised modules it can also be upgraded for larger batches and fully automated production, offering drug producers the flexibility to adapt to market demands.

Bosch expands the portfolio for continuous manufacturing with the new Xelum R&D. The entry-level unit will be presented to selected customers for the first time at Achema 2018.

It is based on the Xelum platform, which was especially developed for continuous production by the Bosch subsidiary Hüttlin.

The Xelum R&D stands for short development times with a low API consumption rate. It offers customers the shortest way from development to continuous manufacturing – without time-consuming scale-up.

The GKF 720 is another market novelty. Its washable containment, the flexible platform for small batches, sets new standards in the safe processing of highly potent solid dosage forms. Customers benefit from fast product changes and short cleaning times with low water consumption.

The pharma portfolio is complemented by matching secondary packaging solutions. Amongst others, Bosch showcases the CPS 1900 WTE module with Tamper Evident function and integrated checkweigher for the reliable serialisation of folding cartons. The new reworks station allows for easier handling of all serialisation and aggregation data – even beyond production completion.

New Industry 4.0 solutions and comprehensive service portfolio Apart from safety along the supply chain, Bosch's Industry 4.0 solutions also ensure transparency in production. Real-time information provides customers with all necessary data to monitor the machine status or process parameters. In addition to data services, Bosch showcases the new Pharma MES:SE.

The starter edition of the browser-based software solution for GMP environments captures, stores and visualises machine data. Just like with all other industry 4.0 solutions, Bosch combines the own software and processing expertise to offer customers a solution which is exactly tailored to the requirements of the pharmaceutical industry. Operators profit from quick reaction times in case of deviations. The Pharma MES:SE also helps to analyse and improve overall equipment effectiveness (OEE).

By capturing machine data, services such as predictive or preventive maintenance and remote service can be used more effectively. Thanks to Bosch's global presence with local service technicians and training centers, as well as the online ordering platform E-Portal, customers receive comprehensive worldwide after-sales services.

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