Phico Therapeutics awarded Innovate UK funding

Published: 2-Aug-2018

The funding will support development of a Pseudomonas aeruginosa targeted therapeutic, to tackle the genetic cause of antibiotic resistance

Phico Therapeutics, a biotechnology company developing a novel platform technology as the basis of a new generation of antibiotics to overcome antibacterial resistance, has been awarded significant funding to support the manufacturing development of its intravenous antibiotic, SASPject PT3.8.

Innovate UK, the UK’s innovation agency, will provide £1.4 million to support the project, which will be undertaken in partnership with The Clinical Trial Company and GE Healthcare.

Phico is developing SASPject PT3.8, an antibacterial therapy for the systemic treatment of patients with serious Pseudomonas aeruginosa infections, which have a high mortality rate.

P. aeruginosa causes a wide range of infections, most frequently in hospitals, and is very difficult to treat, due to the organisms/bacteria’s intrinsic antibiotic resistance mechanisms, including an impermeable cell membrane and efflux pumps, which can remove antibiotics that do enter the cell.

As clinical trials are expanded, it is anticipated that the product will also be used in situations where a P. aeruginosa infection is suspected but yet to be confirmed, further extending the market opportunity for SASPject PT3.8.

SASPject PT3.8 has been developed using Phico’s SASPject platform, which utilises a unique antibacterial small acid-soluble spore proteins (SASP), to target and deactivate bacterial DNA, stopping bacteria from metabolising or reproducing. The Innovate UK funding will be used to improve the manufacturing yield of PT3.8.

This includes the manufacture of a 15 litre pre-GMP batch for formal pre-clinical testing and development of a quality management system (QMS) for manufacturing at Phico. As partners in the project, The Clinical Trial Company is developing the QMS and GE Healthcare advising on practical manufacturing processes. The programme cost will total £2 million ($2.65 million USD), and the remaining funds will provided by Phico’s shareholders.

Dr Heather Fairhead, CEO at Phico, said: “Our goal is to advance the science of antibacterial therapy to help overcome the global problem of bacterial resistance. This non-dilutive funding from Innovate UK is an important validation of our platform, and will enable us to take our lead product towards testing in humans.”

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