A new breed of antibiotics has revealed promising results in research released by Queensland University of Technology (QUT), to help overcome one of the biggest modern medical challenges, bacterial biofilms. The new antibiotic has scope to be applied beyond medicine, to agriculture, biotechnology and other industries.
Bacterial biofilms are a leading cause of failing antibiotic therapies and chronic infections. QUT researchers have developed hybrid antibiotics designed to penetrate the slimy shield protecting invasive golden staph (Staphylococcus aureus) infections.
Led by Associate Professor Makrina Totsika and PhD student Anthony Verderosa, the research has been published in top infectious diseases journal Antimicrobial Agents and Chemotherapy.
The study found hybrid antibiotics worked well by destroying Staph biofilms grown in the lab.
Verderosa explained that biofilms are sticky, slimy coatings that often prevent conventional antibiotics from accessing bacterial cells.
“We have developed a new breed of antibiotic that tricks biofilms into releasing their protected cells allowing access through the protective slimy coating of the biofilm,” Verderosa said. “This allows for the biofilms to be eradicated.”
Verderosa added that the microscopic compound emits a fluorescence signal enabling researchers to watch the drug penetrating the biofilm, either killing the bacteria directly or leaving them susceptible to killing.
QUT Associate Professor Makrina Totsika and PhD student Anthony Verderosa have developed hybrid antibiotics in the fight against staph infections
Associate Professor Totsika said the majority of infections involve biofilms in some way so the potential for these drugs is wide.
“We are now gearing up to do pre-clinical testing,” she said. “What is promising is the fact that our compounds are hybrids of drugs that are already in clinical use as stand-alone therapies, such as conventional antibiotics and nitroxides, so this offers hope that they could be translated into clinical therapies in the not so distant future.”
Hospital-acquired infections and increasing resistance to antibiotics has challenged medical researchers to find and test novel antimicrobial agents, including alternatives to antibiotics. The World Health Organisation has identified antibiotic-resistant pathogens as one of the “biggest threats to global health today”.
Associate Professor Totsika said there was scope to apply the research beyond medicine, to agriculture, biotechnology and other industries. She is the recipient of a QUT Vice-Chancellor’s Research Fellowship, and her research is supported by grants from the National Health and Medical Research Council and the Australian Research Council.
Researchers involved in developing the hybrid antibiotics came together from QUT’s Infection and Immunity Research Program as well as the Molecular Design and Synthesis Chemistry program.
Research authors: Anthony D Verderosa, Rabeb Dhouib, Kathryn E Fairfull-Smith, Makrina Totsika.
