Intertek has more than 15 years' experience of providing comprehensive GLP/cGMP analytical support to clients involved in oligonucleotide development and manufacturing.
There is a requirement for robust and accurate analytical characterisation strategies for assessing composition and purity of these complex products (siRNA, Antisense oligonucleotide (DNA-like) or Aptamer) and starting materials. One key technique is 31P NMR and its application to structural characterisation and P containing impurities.