TTP LabTech has introduced the RAPid 4, a flow-based analysis system using the latest technology to performs label-free interaction analysis.
The detection of molecular interactions is achieved through Resonant Acoustic Profiling technology, which offers substantial advantages over optical biosensors. It reduces the need to purify samples and generates accurate kinetic, affinity and concentration measurements from complex biological mixtures, such as blood, serum, cell culture supernatants and periplasmic extracts.
RAPid 4 is suitable for use in pharmaceutical laboratories for biotherapeutic development and protein expression analysis and the system allows the label-free detection of molecular interactions in real-time.
The acoustic system enables the determination and quantification of protein interactions in buffered solutions and in complex mixtures that may contain solvents, serum, growth media or other impurities. In addition, the collected data can be used to accurately determine the concentration of target molecules across a broad dynamic range.
Currently, few technologies offer life scientists the ability to detect real-time kinetic data of this quality across such a broad range of samples, sample purities and concentrations. RAPid 4 can analyse up to four samples, or combinations of samples and control materials in parallel, typically processing an average of 350 samples per day. The instrument is a fully automated platform, requiring minimal user intervention and running unattended for up to 72 hrs.