Alizyme pleased with results of phase 11b clinical trial for cetilistat in obese diabetics

Published: 12-Dec-2005

Alizyme of Cambridge, UK, says preliminary results of its Phase IIb clinical trial of cetilistat in clinically obese diabetic patients were good. The trial met its primary endpoint of showing statistically significant weight loss.


Alizyme of Cambridge, UK, says preliminary results of its Phase IIb clinical trial of cetilistat in clinically obese diabetic patients were good. The trial met its primary endpoint of showing statistically significant weight loss.

The objectives of the study were to determine the effect of cetilistat on weight loss and on markers of diabetes, together with its safety and tolerability profile, in clinically obese diabetic patients having a Body Mass Index between 28 and 45, with their diabetes managed with the antidiabetic drug, metformin.

Thel trial enrolled 612 clinically obese patients across five European countries, including the UK. Professor Peter Kopelman, principal investigator said: 'This trial has confirmed the potential utility of cetilistat for the management of obese diabetic patients. The substantial reduction in the number and severity of the adverse events experienced by patients taking cetilistat is very encouraging. A crucial element for the successful management of obesity is the patient's adherence to their prescribed medication'.

Dr Richard Palmer, Alizyme ceo said: 'These results confirm the commercial potential of cetilistat, and allow us to prepare for Phase III development, whilst continuing dialogue with potential licensing partners.'

  

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