Alltracel reports positive results on cholesterol

Published: 20-Apr-2005

Alltracel Pharmaceuticals has reported on preliminary findings on its patient trials covering the cholesterol-lowering efficacy of the m.doc technology platform.


Alltracel Pharmaceuticals has reported on preliminary findings on its patient trials covering the cholesterol-lowering efficacy of the m.doc technology platform.

Preliminary findings from two placebo controlled human studies (both double blinded and single blinded) on two formulations of m.doc; which covered 100 EU based patients with various levels of elevated cholesterol, indicated the following:

• Post-trial preliminary safety results showed no adverse affects and further analysis indicated no safety concerns. Detail on this will be confirmed as part of the full medical report currently being prepared.

• Following a three-week treatment regime the majority of people in the active treatment groups showed a statistically significant reduction in LDL cholesterol levels. This LDL reduction is comparable to that seen with commercially available sterol based products.

Tony Richardson, chief executive officer, Alltracel Pharmaceuticals, commented: 'These significant patient trial results indicate the cholesterol lowering and overall coronary health benefits of the m.doc technology platform identified in our pre-clinical work over the past 18 months also applies to humans.

'Previous pre-clinical results demonstrated that as well as both reducing LDL cholesterol and improving the HDL/LDL** ratio; m.doc also shows significant longer-term coronary health benefits specifically in the area of arterial plaque build-up prevention.

'In addition this pre-clinical work showed significant indications that the m.doc coronary health benefits are additive in nature, to both statins and sterols.

'We are now focusing on further efficacy, dosage and timing/phasing studies to determine optimum delivery systems, formats and combinations in both the nutraceutical and pharmaceutical markets.

'We have commenced development discussions with potential partners in both the nutraceutical and pharmaceutical sectors in both the EU and North America and it is likely that some of these studies will be in collaboration with development partners.'

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