The Heidolph Synthesis 1 has a modular design that allows both solid and liquid phase reactions to be run and evaporated on one basic unit of equipment, saving space, time and cost, according to UK distributor Asynt.
All the transparent reaction vessels are mounted around the circumference of the heating block, giving good sample visibility and access. Reaction vessels from transparent PTFE and PFA are available combining exceptional chemical resistance with non-stick properties that prevent adherence of sample or resin to the tube wall.
Mixing is achieved by frequency-controlled shaking at speeds from 100 to 1000rpm. With heterogeneous samples this has been shown to be more effective than magnetic stirring, exhibiting fewer scale-up effects.
Up to 24 reaction vessels can be accommodated in four heating zones, each with its own independent temperature control, making it suitable for evaporating or refluxing solvents with different boiling points. Reaction volumes range from 8 ml to 50ml. A central connection for vacuum and inert gas supply facilitates running reactions under inert atmosphere.
Direct, in-vessel sample temperature feedback from each zone ensures accurate temperature control to ±1°C. Up to four programmable temperature ramps can be applied to each zone over the unit's temperature range, from -80°C (with external chiller) to +160°C. The integral process timer allows completely unattended operation.