Countable Labs has announced a comarketing agreement with Promega, a leader in providing innovative solutions and technical support to the life sciences industry.
The agreement brings together the capabilities of the Promega Maxwell System for nucleic acid extraction and the Countable PCR instruments for complete, bias-free DNA and RNA extraction and quantification.
The combined workflow leverages the Promega Maxwell System, a reliable, fast, and simple automated benchtop nucleic acid extraction instrument, which uses a paramagnetic, particle-based workflow to process up to 48 samples in parallel, delivering high-quality nucleic acids for a broad range of downstream applications.
The nucleic acids are then analysed with Countable PCR instruments, isolating single molecules across 30 million compartments for true single-molecule quantification and using the majority of extracted material as input — interrogating samples more completely to maximise detection of rare targets that other methods miss.
In a poster published by Countable Labs illustrating the utility of the workflow, total cfDNA was extracted from human blood plasma using a magnetic bead-based automated system (the Rapid ccfDNA Kit on the Maxwell CSC system) to ensure consistent recovery from low-input material.
When coupled with a preamplification step, a multiplexed KRAS assay using Countable PCR reached 0.08% MAF for G12C without compromising sensitivity for multiplexing.
Results were reproducible across technical replicates and were achieved with minimal optimisation.
Countable Labs is on a mission to unlock new possibilities in rare variant detection and quantification by delivering the high sensitivity and robust scale that traditional PCR methods have never achieved.
“Countable PCR's ability to spatially isolate and detect single molecules across 30 million compartments makes it an efficient solution for a range of translational research and diagnostics challenges from monitoring minimal residual disease to pushing the boundaries of liquid biopsy,” said Anjali Pradhan, Chief Business Officer at Countable Labs.
“Partnering with Promega gives our customers a seamless, end-to-end solution from sample to answer, empowering a new wave of precision medicine innovation.”
“Promega and Countable Labs are aligned in our desire to provide flexible, best-in-class solutions for life sciences’ biggest technological challenges,” said Alok Sharma, Global Clinical Market Director at Promega.
“We designed our Maxwell instruments and kits to provide the versatility our customers can trust, enabling experiments that reliably and efficiently deliver high-quality nucleic acids from a broad range of sample input types and amounts, enabling many downstream applications.”
