CPhI news: Dow Wolff shows new excipients and coatings
Dow Wolff\'s new excipients and coatings help get products to market faster and more cost-effectively
Under the slogan 'Formulation Yields Innovation', Dow Wolff Cellulosics (DWC) is looking with its latest ingredients to help manufacturers create significant efficiencies, improve formulation and delivery flexibility, and to support cost containment.
For example, its recently launched Methocel DC Premium Grade, a hypromellose excipient for direct compression of controlled release applications, is said to provide better powder flow while maintaining key drug formulation attributes, such as tablet hardness and controlled release drug performance.
By eliminating the wet granulation process, Methocel DC Premium Grade can lead to manufacturing cost savings of up to 30% as well as faster scale-up, compared with the traditional tablet manufacturing processes that include the wet granulation process.
This product is being distributed via the Controlled Release Alliance DWC formed with Colorcon in 2007.
DWC will soon release a further Methocel excipient – Methocel Premium VLV – for use in a new coating technology that can reduce coating time by up to 54 % compared with Methocel Premium E-LV.
The ingredient enables faster coating time because less water and other solvents need to be evaporated. It enables up to 52 % higher solids loading of the coating solution, while maintaining sprayable viscosity, and increases manufacturing capability resulting in improved productivity.
Another advancement is the DWC foam granulation technology – a faster, simpler, and more cost-effective process than traditional wet granulation, changing the way pharmaceutical tablets have been manufactured for the past 50 years.