Drug development can be a gas

Published: 15-Apr-2013

The pharmaceutical and biotech industries rely heavily on industrial gases for applications such as supercritical fluid chromatgraphy and lyophilisation. Gas supply systems theefore need to offer high purity and traceability through the supply chain

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Speciality gas use in drug discovery, production and preservation is key. Linde Gases reviews the increasing need for gas purity and traceability.

Both the pharmaceutical and biotech industries are heavily dependent on industrial gases. They are employed as ‘invisible helpers’ in most areas of the industry – from high-purity speciality gases for lab use, to process gases for production of active ingredients and drugs, in the development of chemical synthesis, as sterilisation gases, as gas mixtures to grow biological cultures and also for quality control.

‘With the immense cost associated with bringing a new drug to market and the speed at which companies are today required to do this, finding the correct molecular candidate and then being able to trust in the validity of the result is absolutely essential,’ says Katrin Åkerlindh, Global Product Manager for Speciality Gases & Speciality Equipment at Linde Gases Division.

As a result, the use of analytical instruments such as gas chromatographs with multiple detectors, liquid chromatographs coupled with mass spectrometers, UV/VIS spectrometers, and NMR spectrometers are essential in pharmaceutical labs. These instruments need carrier, detector and purge gases and might also require calibration gas mixtures with known degrees of accuracy, purity and composition.

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