GE Healthcare launches new purification tools

UK-based company GE Healthcare has added two new products to its MabSelect family of products designed to meet growing industry needs for the purification of monoclonal antibodies (MAbs).

MabSelect Xtra and MabSelect SuRe are said to offer the highest purity and most time and cost efficient chromatography media on the market for the industrial purification of MAbs.

MabSelect Xtra (eXtra capacity) is a new recombinant protein A-based chromatography medium that captures antibodies with improved efficiency and economy. It is engineered to give 30% higher dynamic binding capacity than other commercially available protein A-based media, according to GE Healthcare, resulting in lower cost of production, especially when capturing antibodies from high-expression feedstocks.

MabSelect SuRe is a chromatography medium based on a novel alkali-stabilised protein A-derived ligand engineered to provide greater stability than conventional protein A-based media in the alkaline conditions used in cleaning-in-place (CIP) protocols. The use of sodium hydroxide with MabSelect SuRe is said to result in lower costs for cleaning and fewer failed batches. The medium is suitable for regular production or in early clinical phases/process development.

'The success of monoclonal antibodies as therapeutics for the treatment of cancer and immunological diseases has driven the need for more time efficient and cost effective tools for the development and manufacturing of these antibodies on an industrial scale,' said Peter Ehrenheim, president of protein separations at GE Healthcare. 'GE Healthcare is committed to helping customers handle larger volumes of higher titer feedstock while increasing yield to help reduce the overall cost of production. This will ultimately lead to the creation of promising new agents for human therapy.'