German and Dutch firms join Theraptech project

Published: 4-Mar-2009
Sustainability Research & Development

Alloksys Life Sciences, CEVEC Pharmaceuticals and PharmaCell have embarked on a Euro 2.4m therapeutic protein development programme subsidised under the European Trans Bio Programme.


Alloksys Life Sciences, CEVEC Pharmaceuticals and PharmaCell have embarked on a Euro 2.4m therapeutic protein development programme subsidised under the European Trans Bio Programme.

The major objective of the Theraptech programme is to develop a recombinant human alkaline phosphatase (rhuAP) using the novel versatile human CAP cell line, which has been shown to efficiently express glycosylated proteins.

The rhuAP produced in CAP cells is expected to feature an improved pharmacokinetic and safety profile allowing for repeated dosing of alkaline phosphatase in chronic diseases such as rheumatoid arthritis.

The combined expertise of consortium members is said to cover the spectrum of activities needed to drive the project from molecular biology to GMP-production and recombinant product testing in preclinical and clinical trials, pushing towards a clinical phase II compliant product within the three-year timeframe of the project.

Netherlands-based Alloksys Life Sciences is a biopharmaceutical company dedicated to the r&d of therapeutic proteins for the treatment of both acute and chronic inflammatory diseases.

CEVEC Pharmaceuticals in Germany specialises in developing therapeutic proteins and monoclonal antibodies with human glycosylation patterns.

PharmaCell, also based in The Netherlands, provides contract services in the area of human cell and tissue banking and culturing, as well as human cell line development and manufacturing of biopharmaceuticals.

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