Lonza Biologics to evaluate Chromos delivery technology

Published: 1-Jul-2002
Sustainability


UK-based Lonza Biologics has entered into an agreement with Canadian biotechnology company Chromos Molecular Systems to evaluate the latter's proprietary chromosome-based gene delivery and expression technology with its mammalian cell lines for improved expression of proteins. The agreement is for one year, with an option to license Chromos's ACE System with Lonza's GS gene expression system for use in cellular protein production.

Chromos is using a unique mammalian chromosome technology platform from which multiple product candidates can be developed. The ACE System is a unique and powerful vehicle for carrying genes into cells that is said to offer competitive advantages over current systems in that it permits the rapid and efficient insertion of selected genes, allows for the long term and stable expression of large, single or multiple proteins, and provides a means to selectively and predictably control protein expression.

'A severe global shortage of manufacturing capacity for protein therapeutics is imminent,' said Alistair Duncan, president and ceo of Chromos. 'We believe the potential exists to use our technology to considerably decrease the time to production through its speed, ease of use and predictability for rapidly engineering protein expressing cell lines. This agreement with Lonza provides an opportunity to have the capabilities of our ACE System evaluated in the field of cellular protein production by one of the world's largest contract manufacturing organisations.'

Chromos's near-term commercial focus is in the application of its ACE System for use in cellular protein production to generate therapeutic proteins. The technology enables the rapid engineering of cell lines so that they can carry specific genes in target cells to express proteins in a controlled and predictable manner. The ACE System can function in a wide variety of mammalian cell types including those used in the industry for protein production.

'We believe this collaboration could provide us with the ability to progress products more rapidly through development and into cGMP production on behalf of our clients,' said Markus Gemuend, Lonza Biologics' president and ceo of Lonza Group. 'Chromos's ACE System could complement the success of our own proprietary GS Gene Expression System and could offer an even more powerful tool in the field of cellular protein production.'

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