Using a custom designed heating block to fit UPLC autosampler
Asynt, a chemical synthesis specialist based in the UK, has supplied a European Contract Research Organisation (CRO) with a custom heating block system to assist chemists analysing the thermal stability of multiple samples being prepared for its commercial compound libraries.
The CRO had previously used an offline heating source to heat samples coming from its UPLC system – a labour-intensive process involving manual transfer of samples to and from the UPLC autosampler.
A new, efficient method was developed with chemists at Asynt using a custom designed heating block with locators and format to fit the UPLC autosampler as well as an offline heating tray compatible with a hotplate stirrer.
The new system has been demonstrated to provide more uniform heating to all UPLC samples, eliminate sample mix-ups and significantly reduce the labour intensity of the whole process.
The CRO reports that the system has not only improved productivity, but is also producing more accurate, repeatable thermal stability measurements.