Particle velocimetry, exemplified in the Parsum inline particle probe (IPP70) from Malvern Instruments, is a technique that is suitable for measuring particles in the size range 50 to 6000µm, travelling at velocities of between 0.01 and 50m/s. This makes it ideal for monitoring processes such as granulation, spray drying, fluidised bed and particle size reduction.
The importance of granulation in pharmaceutical manufacturing is well established, where it is used widely to improve the flow properties and consistency of tableting blends, as well as for other properties. High shear (or wet) granulation delivers high throughput and dense, uniform, dust-free granules, but its optimisation can be challenging. Continuous monitoring offers a valuable approach.
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