Merck Millipore introduces compaction technology to improve solubility

Dry compression process compacts powder media used in biopharmaceuticals into granules

Merck Millipore has introduced a technology that compacts dry powder cell culture media into granules, accelerating solubility and improving flowability and handling. The compacted media are therefore more convenient to use, allowing biopharmaceutical manufacturers to improve the efficiency of their upstream processes.

The technology is water- and additive-free and applies compression force to Merck Millipore's homogenous dry powder media, fixing that homogeneity in place and creating granules several millimetres in size. The company says the process does not alter the media's amino acid or vitamin composition, and leaves intact the physico-chemical parameters of dissolved media and feeds, preserving the media's ability to support cell growth and productivity.

Merck Millipore will use compaction technology to produce customised cell culture media formulations for customers' specific process needs. The company also plans to use it to enhance its established portfolio of cell culture media products.

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