MilliporeSigma publishes white paper on single-pass tangential flow filtration

In this mode of TFF, the feed solution is pumped once through a set of filters arranged in series to produce permeate and concentrated retentate

Current trends in the biopharmaceutical industry are driving the implementation of high capacity processes capable of reducing costs and footprint without sacrificing manufacturing efficiency and product quality. A step in the biomanufacturing process that enables such convenience is ultrafiltration with single-pass tangential flow filtration (single-pass TFF).

Single-pass TFF is an enhanced approach to the existing TFF technology that has been used for the purification of monoclonal antibodies, therapeutic proteins, and vaccines at different steps within downstream processing. In this mode of TFF, the feed solution is pumped once through a set of filters arranged in series to produce permeate and concentrated retentate. The once-through flow path of single-pass TFF offers the advantages of reduced footprint, shear exposure, and working and hold-up volumes, which in turn lead to higher plant productivity.

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