Novel Valois valve selected for buccal insulin pMDI

Published: 9-Feb-2007
Packaging Drug Delivery Pharmaceutical

French company Valois Pharma, a specialist in the design, development and manufacture of non-invasive proprietary drug delivery devices, has been selected by US-based Generex Biotechnology Corporation to provide a unique delivery system for Generex Oral-lyn - an insulin therapy delivered via pressurised Metered Dose Inhaler (pMDI) through the buccal cavity.


French company Valois Pharma, a specialist in the design, development and manufacture of non-invasive proprietary drug delivery devices, has been selected by US-based Generex Biotechnology Corporation to provide a unique delivery system for Generex Oral-lyn - an insulin therapy delivered via pressurised Metered Dose Inhaler (pMDI) through the buccal cavity.

Generex Oral-lyn has been approved for sale in Ecuador for treating Type 1 and Type 2 diabetes and is in various stages of clinical trials around the world. Generex is preparing a pivotal Phase III study in the US.

The novel valve developed by Valois Pharma for Generex Oral-lyn is a patented large dose metering valve - a key component of the pMDI that will be included within the existing DMF for DF10 class valves. The Valois Pharma valve uses special metal componentry that was developed in partnership with Presspart, a leading manufacturer of metal components for drug delivery systems.

This novel valve is part of a range of innovative drug delivery devices offered by Valois Pharma that includes Landmark, the recently developed dose indicator for pMDIs.

'We believe the rapid absorption by the buccal mucosa coupled with the dose accuracy and the convenience of the pMDI make it an ideal non-invasive alternative drug delivery solution for diabetes and other therapies,' said Salim Haffar, vice president sales & business development, pulmonary at Valois Pharma.

Valois Pharma, a division of Valois S.A.S., specialises in nasal and pulmonary drug delivery technologies with a broad product range that also provides solutions for other drug delivery routes such as buccal/sub-lingual, throat and dermal/transdermal.

Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The company's proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth its proprietary RapidMist device.

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