SF-Chem opens three new routes

SF-Chem, from Pratteln, Switzerland, has released three new product families. Benzo-β-thiophene, 4-alkanoylphenol and 4-alkylphenol derivatives have been developed to offer new synthetic drug discovery routes.

The alkanoyl and alkyl compounds are based on a reaction of acid chlorides and hydroxybenzene. Subsequent rearrangement leads to the corresponding alkanoylphenol derivatives. Further hydrogenation of the carbonyl group leads to the alkyl substituted derivatives. For the synthesis of Benzo-β-thiophene derivatives several routes are possible, and the main use of the products is in drugs for osteoporosis, antiallergica and antiasthmatic treatments.

Another company highlighting its technology was Boron Molecular. Based in Noble Park, Victoria, Australia, Boron Molecular has developed organoboron compounds used in the coupling of molecules via carbon-carbon bonds in the Suzuki reaction. This involves coupling a boronic acid or boronic acid ester derivative of an organic residue with an organic halide or pseudo halide.

Because the technologies used are tolerant of the nature of the substituents introduced on the organoboron derivatives, the need to protect and subsequently deprotect substituents is, therefore, minimised. This allows the production of complex and novel organoboron compounds, previously too expensive or difficult to synthesise with other methodologies.