Aptamer and Neuro-Bio collaborate on Alzheimer’s disease diagnostic

Published: 14-Jun-2023

The novel Alzheimer’s disease biomarker was discovered and is currently being further validated by Neuro-Bio, led by neuroscientist Baroness Susan Greenfield

Aptamer Group and Neuro-Bio, an Oxford-based biotechnology company with a therapeutic focus on neurodegenerative disease, have announced success in the development of Optimer binders to enable a lateral flow test for the early diagnosis of Alzheimer’s disease.

Aptamer Group has successfully developed a panel of Optimer binders to a novel Alzheimer’s disease biomarker. The Optimer binders have been patented by partners at Neuro-Bio, following the demonstration of performance in specifically binding to the target biomarker and functionality in a nasal mucous matrix. Further integration of the binders into a routine lateral flow test will support the clinical and commercial development of rapid diagnostics for Alzheimer’s disease via simple nasal sampling, with the potential to diagnose the disease as early as 10-20 years before symptoms emerge.

The novel Alzheimer’s disease biomarker, a peptide ‘T14’was discovered and is currently being further validated by Neuro-Bio, led by the eminent neuroscientist Baroness Susan Greenfield. Early detection of Alzheimer’s disease is critical to allow interventions that could prevent the onset of devastating memory loss and confusion in these patients. Neuro-Bio is working in parallel to develop a complementary therapy that could stabilise disease progression in diagnosed patients, ideally at the presymptomatic stage.

The advancement of new biomarkers and diagnostics in this field offers hope to the millions of patients and their loved ones worldwide

Dr David Bunka, Chief Technical Officer of Aptamer Group, will take part in Neuro-Bio’s Science Day today at the Royal College of Physicians, discussing the development of the Optimer binders in partnership with Neuro-Bio, and the potential for diagnostic development.

Dr Rob Quinn, Interim CEO of Aptamer Group, commented: “We are pleased to be able to support the team at Neuro-Bio with the development of Optimer binders to enable their revolutionary diagnostic for Alzheimer’s disease. Optimer binders have proven performance in lateral flow test formats and our success in delivering functional Optimer binders to Neuro-Bio’s biomarker facilitates further diagnostic development. With an increasingly ageing population and no current tests available for early-stage diagnosis, the advancement of new biomarkers and diagnostics in this field offers hope to the millions of patients and their loved ones worldwide.”

Baroness Susan Greenfield, CEO of Neuro-Bio, commented: "We’re delighted to be working with Aptamer Group on this potentially game-changing technology to combat one of the biggest unmet medical needs of our time. It’s a further example of UK ingenuity and teamwork for highly innovative and disruptive science."

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