BioIVT acquires Cypex, a leading manufacturer of drug-metabolising enzymes

Published: 9-Aug-2022

Cypex’s recombinant xenobiotic metabolising enzymes complement BioIVT’s extensive portfolio of hepatocytes and related hepatic products for drug research and development

BioIVT, a leading provider of biospecimens, research models and services for drug and diagnostic development, today announced that it has acquired Cypex, a renowned manufacturer of recombinant xenobiotic metabolising enzymes, based in Dundee, Scotland. Cypex’s extensive enzyme portfolio covers a wide range of proteins involved in drug metabolism.

“We are delighted that the Cypex team is joining BioIVT, bringing with them not only their market-leading products, but also their in vitro drug metabolism technology expertise,” said BioIVT Chief Executive Officer Richard Haigh.

“The acquisition of Cypex enhances BioIVT’s product portfolio, ensuring that we continue to meet all our biopharmaceutical customers’ research requirements for their entire R&D pipeline.”

“This is a good match. We view BioIVT as a like-minded partner; we share the same commitment to supplying high quality products and passion for ensuring that our customers have the best products for their research,” said Dr Michael Voice, Lead Scientist at Cypex.

“We are excited that our customers will gain access to BioIVT’s hepatocytes and other hepatic products, and benefit from its well-established global biospecimen network, and robust supply chain.”

Product development

Cypex’s products are produced using a patented technology, which was developed by the University of Dundee in partnership with several leading international pharmaceutical companies.

This technology enables the expression of human drug-metabolising enzymes in bacteria, without requiring large modifications to the proteins.

Since the introduction of its first recombinant CYP enzyme in early 2000, Cypex has built an extensive product range, which contains more than 115 recombinant enzymes, including CYPs, UGTs, CES, and AOX, and companion chemicals and media.

Also offered are services for inhibition screening, protein expression and drug metabolite generation. These products and services are used to generate in vitro data showing how a candidate drug will be metabolised in the human body, data often included in new drug applications to regulatory agencies.

BioIVT will continue to operate from the ISO 9001 certified manufacturing facility in Dundee. Financial details about this transaction were not disclosed.

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