CHOP and BTS join forces
Bayer Technology Services and the Children's Hospital of Philadelphia (CHOP) have entered into a collaboration to bring the advantages of pharma-cokinetic and pharmacodynamic modeling and simulation techniques into the clinic.
Bayer Technology Services and the Children's Hospital of Philadelphia (CHOP) have entered into a collaboration to bring the advantages of pharma-cokinetic and pharmacodynamic modeling and simulation techniques into the clinic.
The project combines BTS's proprietary physiology-based pharmacokinetic (PBPK) simulation software, PK-Sim, with CHOP's in-house data-driven population models to optimise an individual drug therapy for children.
The models will be integrated into CHOP's 'Pediatric Knowledgebase,' a CHOP-funded initiative that aims to bring modeling and simulation for patient-optimised care into the clinic by creating a user-friendly graphical computer interface. This software will present the attending physician with all relevant patient information and dosing history as well as predict, through simulation, the expected trends in drug plasma concentrations. This will allow for in-formed dosing decisions specific to each child.
The PK-Sim software contains physiological and clearance information for children of all ages and supports the prediction of pharmacokinetics for use in personalised dosing. The technique is well suited for extrapolating pharmacokinetics in chil-dren with atypical physiology and pathological conditions.