The impact of machine change parts in OSD manufacturing and R&D

Published: 12-Feb-2026

One machine. Fewer change parts. Lower GMP risk. Author: Phillip Ruda

Why “universal” OSD weight sorting is becoming a strategic requirement, not a nice-to-have. Pharma has a long history of learning the hard way that complexity is a quality risk. Every additional component you introduce into a changeover, every extra chute, bowl, guide, track, gate, insert, or format kit, creates more opportunities for:

  • residue carryover
  • parts mix-ups
  • undetected damage / wear
  • incomplete cleaning verification
  • documentation gaps
  • line-clearance failures

The industry often treats “change parts” as an operational detail. Regulators don’t. They treat them as product-contact surfaces and potential contamination vectors, and they expect you to control them with the same discipline you apply to the machine itself. That’s why the idea of a weight sorter that can handle almost all tablet and capsule formats with no dedicated format parts isn’t a “nice usability feature”. It’s a way to design out risk and it aligns directly with the direction GMP has been moving for the last decade.

The impact of machine change parts in OSD manufacturing and R&D

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