Process systems and operation experts have launched a crystallisation monitoring startup, Crystallization Systems Technology (CrySyst).
The company, founded by Professor of Chemical Engineering at Purdue University Zoltán Nagy and postdoctoral research associate at Purdue, Botond Szilágyi, aims to streamline pharmaceutical crystallisation processes for more efficient drug manufacturing.
CrySyst's quality-by-control framework will facilitate the monitoring, modelling and control of the crystallisation process, and is based on research published in two issues of the journal Crystal Growth & Design, as well as an issue within the Industrial & Engineering Chemistry Research journal.
CrySiV and CryMoCo
According to Nagy, "the most significant challenges in model-based process development come from determining what experiments are necessary, selecting the most appropriate model structures and obtaining reliable model parameters."
The company's tools aim to address the crystallisation pain points by "providing guided experiment selection while also offering a semi-automated framework for model development."
"By utilising CrySiV and CryMoCo, pharmaceutical companies can develop a streamlined, systematic and scientifically rigorous approach to crystallisation process development," noes Nagy.
The tools can also reduce the time needed for process development, as well as material usage and risk while boosting a process' scalability.
Purdue University's Innovates Office of Technology Commercialization has issued a license for CrySyst to commercialise copyright technologies from both CryMoCo and CrySIV.
CryMoCo is a vendor-independent crystallisation process monitoring and control software, which incorporates direct nucleation and supersaturation control approaches — enabling the rapid direct design of robust crystallisation processes.
CrySiV is an interactive population balance model-based crystallisation simulator, which allows users to digitally design crystallisation processes. This includes kinetic parameter regression, process simulation and visualisation.
“CrySiV also includes process optimisation features for both crystallisation and integrated crystallisation-wet milling processes, using state-of-the-art numerical methods for modelling and optimisation,” Nagy says.