FMC offers spray dried excipient for dry granulation processes
The spray dried MCC/DCP excipient enables producton of solid dosage forms using roller compaction
Avicel DG is a new, proprietary co-spray dried MCC/DCP excipient from FMC that is optimised for the use in dry granulation processes.
The characteristics of Avicel DG facilitate solid dosage form manufacturing utilising roller compaction by improving process robustness, tablet hardness, and yields. According to FMC, Avicel DG offers good flow characteristics, high quality initial compactability, required for the production of robust ribbons, and excellent recompactability, resulting in enhanced tabletting performance and fewer rejected tablets.
Avicel DG is the result of a synergistic combination of two pharmaceutical excipients produced using FMC’s expertise in spray dried, co-processing technology.
It is supplied as a white, odorless powder containing 75% of microcrystalline cellulose and 25% anhydrous dibasic calcium phosphate. The wet dispersion and spray drying of microcrystalline cellulose and anhydrous dibasic calcium phosphate results in an intimate physical combination, which cannot be achieved by traditional dry blending.
As an example, a model formulation containing Vitamin C (Ascorbic Acid), lubricant and Avicel DG, compacted at 30 bars, produced tablet tensile strengths 100-175% better than formulations containing physical blends of common excipients.
The use of Avicel DG is claimed to improve yields by dramatically enhancing recompactability and reducing costs by minimizing steps in the production process.