A further challenge to overcome is that the perception of bitterness varies from one individual to another.
Even in today’s age of sophisticated technology, there is still no substitute for human insights, making access to sensory experts who are trained to quantify the intensity of bitterness in different pharmaceutical products vital.
Sensory panellists — usually 8–10 people but sometimes a much larger group — are carefully selected based on their sensitivity to bitterness.
They undergo rigorous training using a well-defined and stringent tasting protocol to ensure consistent and objective assessments and safe working practices when evaluating products containing APIs.11
Standardised scales are used to rate bitterness intensity, enabling reliable comparisons across different formulations to help gauge how they will perform in the market.
The integration of one or more of these approaches enables formulators to benefit from solutions that allow the production of effective, more palatable products, driving better patient adherence to treatment regimens.
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