Hokkaido University develops improved artificial viral vector
An improved artificial viral vector for safely delivering genes into cells for gene therapy has been developed by a research team at Hokkaido University.
An improved artificial viral vector for safely delivering genes into cells for gene therapy has been developed by a research team at Hokkaido University.
Gene therapy currently relies mainly on the adenovirus and other real viruses to carry therapeutic genes into affected cells, but the safety of these vectors has come into question. Artificial viruses are being developed as an alternative, but these kinds of vectors have yet to work effectively.
The new artificial virus can deliver genes into cells with 100 times the efficiency of anything developed to date, according to the research team. It is made from a roughly 100 nm diameter capsule surface-treated to carry molecules that facilitate the capsule's entry into a cell. In addition to genes, this vector can also insert pieces of RNA for the therapeutic strategy known as RNA interference.