Latest EnCat aligns with production trends
The ninth member of Reaxa's EnCat family of encapsulated precious metal catalysts - Pd EnCat polyTPP30 - has been launched with an eye to flow process and microwave heating trends.
The ninth member of Reaxa's EnCat family of encapsulated precious metal catalysts - Pd EnCat polyTPP30 - has been launched with an eye to flow process and microwave heating trends.
PolyTPP30 is an enhanced form containing bound polymeric phosphine ligand and giving extremely low levels of palladium and phosphine contamination in crude pharma products. Contamination levels are typically <5 and <20 ppm for palladium and phosphorous respectively.
It shows good catalytic activity in many C-C bond forming reactions and is adaptable to high-throughput medicinal chemistry processes to deliver improved purity product libraries.
In addition to use in batch processes, its properties enable deployment for flow reaction processes. PdEnCat polyTPP30 has also been successfully employed under microwave-enhanced conditions, delivering both low metal and low ligand contamination of crude products.
"This is one of the first of our second generation. products, optimised for use in flow as well as conventional batch processes," said Reaxa ceo Dr Pete Jackson. "The improved tolerance towards microwave heating is a further benefit to align with new trends in production processes."
As a development catalyst, PdEnCat polyTPP30 samples are currently available direct from Reaxa
Reaxa's current 26-product range includes the EnCat family of nine encapsulated catalysts and 17 QuadraPure and QuadraSil scavenging resins. Key resins are also available in pre-loaded, ready-to-use cartridge format.