Controlled turbulent mixing improves flow chemistry reproducibility

7-Dec-2021

To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions

Uniqsis is expanding its range of Glass Static Mixer (GSM) chip reactor blocks, which produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that are not diffusion dependent.

To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions.

Available in sizes from 270 µl to 20 ml, the range of high-quality GSM chips can be used to perform reactions from -80°C to higher than 150°C. GSM chips up to 2 ml can be operated up to 40-bar and are available in 2-channel or 3-channel inlet configurations. Larger chips of 10 ml and 20 ml have a premixing channel followed by a residence domain and can operate up to 10-bar.

Glass Static Mixer chips can be used as mixing modules prior to a coil reactor residence time unit, or as reactor blocks for rapid exothermic reactions.

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Uniqsis GSM chips are precision machined from inert borosilicate glass to withstand a wide temperature range and can be attached to a FlowSyn column heater module, Cold Coil or Polar Bear Plus cryogenic reactor module.

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