PallSep filtration system gives gentle separation

Pall Corporation, a US filtration, separation and purification specialist, has introduced the PallSep Biotech system for the gentle separation of target molecules from complex biotechnology process fluids.

PallSep Biotech system for the gentle separation of target molecules

Pall Corporation, a US filtration, separation and purification specialist, has introduced the PallSep Biotech system for the gentle separation of target molecules from complex biotechnology process fluids.

The new system uses vibrating membrane filtration (VMF) technology and encapsulated hydrophilic polyethersulfone membrane filter modules, which combine to reduce the accumulation of retained species on the membrane surface, allowing for increased transmission of the target molecule.

The VMF principle is based on the rapid oscillation of porous membrane plates within a process feed stream to create shear at the membrane surface. The generated shear forces are limited to a narrow portion of the flow channel, reducing the amount of process fluid exposed to the shear. The cross flow requirements are much lower with the PallSep Biotech system than with other tangential flow filtration (TFF) technologies, the company says. This creates gentle processing and good product transmission.

The PallSep Biotech system supports the production of high value products such as therapeutic vaccines and antigen extracts. It permits the concentration, clarification and purification of feed streams with high levels of biomass particulates and viscosity, along with difficult-to-filter solutions such as fermentation broths and lysates.

The encapsulated 0.2µm polyethersulfone membrane filter modules, available in filter areas of 0.2, 1 and 5m2, offer flexibility for scale up and scale down of processes. Typical batch sizes range from a few litres to 500L, depending on the process application.




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