CDMO Wheeler Bio has been granted a licence to ATUM’s proprietary Leap-In Transposase and miCHO cell line development technology.
Wheeler Bio solves the typical momentum drop between discovery and development for monoclonal antibodies and other therapeutic proteins. This issue typically poses significant challenges for emerging companies – adding technical, financial, and regulatory risks. Wheeler Bio believes these lifecycle challenges can be reduced with access to industry-leading technologies and the democratisation of standardised manufacturing platforms.
Adding ATUM’s powerful Leap-In Transposase technology to Wheeler Bio’s cell line development toolbox provides Wheeler Bio’s clients with access to highly productive stable pools and clones with a significant regulatory track record and an industry-leading speed-to-clinic workflow.
The Leap-In platform is an excellent fit for Wheeler Bio’s business model and culture of bringing biologics discoveries to the clinic in a robust and cost effective manner
The Leap-In Transposase technology is leading the industry as an incredibly efficient gene delivery system utilising transposon-based vectors to integrate intact DNA constructs into transcriptionally active loci of the host cell genome. When used in a cell line development program, the Leap-In Transposase technology delivers highly productive, incredibly stable and robust cell lines – including at the stable pool stage.
Jesse McCool, Ph.D., Founder and CEO at Wheeler Bio, said: “We are very excited to licence the Leap-In Transposase technology and the miCHO cell line. These tools build on our growing arsenal of enabling tools that drive efficiencies and cost savings in both our custom and platform offerings.”
Oren Beske, Ph.D., ATUM’s Amalgamator of Business and Biology, commented: ”The Leap-In platform is an excellent fit for Wheeler Bio’s business model and culture of bringing biologics discoveries to the clinic in a robust and cost effective manner. We look forward to our partnership enabling the next generation of molecules and entrepreneurs.”
Wheeler Bio will incorporate the Leap-In Transposase technology into its state-of-the-art cell line development platform, including an option for clients to utilise the miCHO cell line. Combining Wheeler Bio’s cell line development service with ATUM’s Leap-In Transposase technology offers all the benefits of transposon-based gene delivery and provides clients the opportunity to progress product candidates rapidly and cost-effectively through preclinical development and into the clinic using Wheeler Bio’s digitised Process Development offering and cGMP manufacturing services.
