The leading cause of therapeutic failure in chronic conditions is patient non-compliance. The proportion of patients who fail to take their prescribed medications in accordance with instructions rises from nearly 40% after 6 months to almost 70% after a year.
The cost of non-adherence in North America alone was estimated to be $337 billion in 2013, so addressing the underlying issues that lead patients to give up on their medicines should be a priority.
There are several factors that affect patient compliance, including route of administration, pattern and frequency of dosing, length of treatment and drug side-effects.
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