Rousselot and IamFluidics have launched a new research-grade, dissolvable microcarrier for adherent cell culturing.
The technology is designed to allow both cell and gene therapy and biologics manufactureres to scale-up their processes, while also streamlining culturing protocols.
To produce this dissolvable microcarrier, IamFluidics has incorporated its IN-AIR MICROFLUIDICS alginate-based product, while Rousselot has provided its denatured collagen.
According to the pair, the dissolvable microcarrier can benefit those culturing cells by:
- Enhancing cell attachment and growth: Denatured collagen promotes cell attachment and growth, while also supporting interactions between cells and the material. These microcarriers are compatible with mesenchymal stem cells and other adherent cell lines
- Promoting efficient harvesting: As the microcarriers dissolve within 15 minutes after cell culturing reagents are added, researchers can efficiently harvest these cells and integrate them into cell expansion systems
- Improving cell yield: With the solution offering scientists more than 90% access to cultured cells, it can significantly reduce cell loss compared to non-dissolvable microcarriers
- Optimising handling: These transparent and monodisperse microcarriers allow for reproducible and easy handling when following standard cell culturing protocols.
Leonard van Bokhorst, CEO of IamFluidics, commented: “Microcarriers are finding success in the expanding cell culturing market,”
“They provide a larger surface for cell attachment than traditional flat (2D) cultures and facilitate scaling up from lab-scale to large-scale bioreactors for efficient commercial production. However, their non-solubility limits efficient cell harvesting. The new dissolvable microcarrier, developed with Rousselot, addresses this challenge.”
“The integration of our innovative IamFluidics’ technology with Rousselot’s unmatched collagen expertise represents a major step forward for the biopharmaceutical industry. This collaboration is set to transform adherent cell culture, offering high yield, cost-effective, scalable solutions for cell-based products and therapies.”
Tanja Vervust, Global Director of Biomedical at Rousselot said, “We are thrilled to collaborate with IamFluidics, whose exceptional expertise and speed of innovation set them apart. By combining our high-quality denatured collagen with their advanced technology, our new dissolvable microcarrier offers the consistency and quality essential for large-scale production. This breakthrough has the potential to accelerate clinical translation, a core focus of all our biomedical solutions.”
