Latest in Cell & Gene Therapy

Zelluna submits UK clinical trial application and publishes preclinical data for ZI-MA4-1 cell therapy for solid tumours

CTA submission to the UK MHRA and peer-reviewed preclinical results mark Zelluna’s transition into the clinic, with first-in-human data for ZI-MA4-1 expected in mid-2026

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Pharma in 2025–2026: AI, China and the new era of drug development

In 2025, the pace of change throughout chemical and pharmaceutical manufacturing is accelerating, creating a complex mix of emerging opportunities and structural challenges...
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Leucid Bio and Syenex team up for in vivo CAR-T cell engineering

The pair will harness Syenex’s VivoCell Platform to precisely deliver Leucid’s CAR-T asset LEU011 construct to T-cells in vivo, representing a next-generation approach and moving toward a simpler, possibly off-the-shelf administration route

BIA report highlights UK innovation and efficiency in global cell and gene therapy sector

The report provides a comprehensive analysis of the UK's cell and gene therapy sector, focusing on the innovative technologies and strategic investments that are driving scale

GenEditBio and ToolGen strike cross-license deal to advance next-generation in vivo genome-editing therapies

The agreement combines ToolGen’s CRISPR-Cas9 platform with GenEditBio’s LNP delivery technology to accelerate development of once-and-done genome-editing treatments
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Standardisation, digital maturity and the path ahead in cell and gene therapy

With the promise of more personalised and potentially curative treatments, regulatory agencies are forecasting a surge in cell and gene therapy (CGT) approvals, reports Dr Matthew Lakelin, Head of Consultancy Services at TrakCel

Thermo Fisher Scientific opens East Coast ATxCC to accelerate cell and gene therapy development

Thermo Fisher has launched its new Philadelphia-based Advanced Therapies Collaboration Center, expanding support for emerging biotechs with integrated lab space, specialist expertise and access to cutting-edge CGT development technologies

Patient dies in CRISPR gene therapy trial

The FDA has now placed Intellia Therapeutics' Phase III CRISPR trials on hold over raised liver enzymes

Touchlight expands mbDNA portfolio with new circular DNA formats for advanced gene therapies

Touchlight has introduced three new circular DNA architectures — sscDNA, hsscDNA and dscDNA — expanding its mbDNA platform to enhance precision, stability and versatility in gene editing and therapeutic development

LYOVAC® ECO Mode: making pharmaceutical freeze-drying leaner and greener

Following the recent announcement that GEA Lyophil has received third-party certification for the energy-saving credentials of its innovative algorithm for freeze-drying applications, Dr Kevin Robinson caught up with Senior Director of Lyophilization Technology Management, Thomas Beutler, to find out more

Latest posts in Cell & Gene Therapy

iOrganBio launches with $2m seed round and unveils CellForge, the first AI-powered cell manufacturing platform

Founded by experts in stem cell biology, organoid systems and biomedical engineering, the company aims to revolutionise how human cells are designed and produced for drug discovery and regenerative medicine

Avant Technologies and Austrianova launch joint venture Klothonova and its groundbreaking Klotho development programme

Using Austrianova's cell-encapsulation technology, the duo aim to engineer a genetically modified cell line that overexpresses the 'longevity protein' Klotho, paving the way for innovative cell-based therapies to combat age-related diseases

Thermo Fisher launches next-gen microarray analyser to accelerate pharmacogenomic research

The analyser combines four key genotyping processes into a single, integrated device, allowing researchers to cover the widest range of populations for genome-wide association studies

Alithea Genomics launches extraction-free, RNA-seq for 3D drug screening and toxicology

The streamlined, one-day workflow delivers full transcriptome coverage in a massively multiplexed manner, making the method ideal for large-scale mechanistic and toxicity studies in 3D models

Bristol Myers Squibb strengthens and diversifies cell therapy portfolio with acquisition of Orbital Therapeutics

Bristol Myers Squibb will acquire Orbital Therapeutics in a $1.5bn deal, adding next-generation RNA-based in vivo CAR T technology to its cell therapy pipeline and expanding treatment potential in autoimmune diseases

Algen Biotechnologies partners with AstraZeneca in $555m deal to advance AI-driven drug discovery in immunology

Algen Biotechnologies has entered a multi-target partnership with AstraZeneca to leverage its AI-powered AlgenBrain platform for identifying novel therapeutic targets in immunology, with the collaboration aimed at accelerating next-generation treatment discovery

CTMC and Einstein Hospital Israelita form global alliance to expand access to cell therapy

The new CTMC Network Alliance will accelerate the adoption of cell and gene therapies across Latin America, aiming to make life-saving treatments more accessible through shared expertise, training and manufacturing innovation

New CGT centre in Bangkok to boost Southeast Asia’s biotech ecosystem

eXmoor Pharma and Siam Bioscience form a strategic partnership to establish leading cell and gene therapy services in Southeast Asia

Huntington's breakthrough: gene therapy appears to slow progression of disease by 75%

uniQure has announced positive topline results from a Phase I/II clinical trial of a new Huntington's disease treatment, spurring hopes that more people at risk will undergo testing

ScaleReady awards nearly $2m in G-Rex grants to advance cell and gene therapy manufacturing in California

The initiative supports leading academic GMP facilities in developing scalable, cost-effective platforms for CAR-T and other cell therapies, reinforcing California’s position as a global hub for CGT innovation

Mana.bio launches pioneering large language model-powered AI agent for lipid nanoparticles

Described as a "ChatGPT for LNPs", LLM Mina will be publicly available at no cost

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PromoCell launches GMP cell culture media services for cell therapy

New offering to debut at 32nd ESGCT Congress, October 7–10 in Seville, Spain

The basics of cell culture

Key steps in manufacturing cell therapies

A smarter alternative to pipette-filling cryovials

By switching to an automated cryovial filling solution, such as award-winning cryoFIL, manufacturers remove one of the most error-prone, resource-heavy steps from their...

The challenges and trends in gene therapy

Three perspectives on the challenges and trends in gene therapy

Andelyn Biosciences adds Stanton Lab CNS Capsids to AAV Curator Platform

Andelyn Biosciences expands AAV Curator® Platform offering to include Stanton Lab CNS Capsids through a license agreement from the Broad Institute of MIT and Harvard

Ensuring cGMP compliance in cell and gene therapy manufacturing

By adhering to GMP principles, manufacturers can mitigate risks, streamline processes, and ensure that their products meet the highest standards of safety and efficacy

Andelyn Biosciences produces viral vector for Nationwide Children’s Hospital using AAV Curator Platform

Andelyn Biosciences AAV Curator® Platform used to manufacture clinical grade viral vector for FDA-Authorised first-in-world Universal Donor CRISPR/AAV Transduced CAR-NK...

Andelyn applies AAV Curator to treat ultra-rare NEDAMSS patient

Andelyn Biosciences applies the AAV Curator platform to deliver novel gene therapy for an ultra-rare NEDAMSS disease patient 14-months after diagnosis

AnalytiChem debuts branded Redipor culture media

The branded culture media line combines the expertise of BioTrading, Redipor by Cherwell and NEL to provide customers with tailored batch sizes, formulations and packaging...

Merck launches single-use reactor designed to accelerate antibody drug conjugate manufacturing

First scalable single-use mixer specifically designed for ADC manufacturing. It increases efficiency by 70% compared to stainless steel or glass manufacturing methods and...

Cell culture bags - Understanding the basics

Uncover the benefits of cell culture bags and why they could be the ideal solution for your cell processing application.

Symbiosis Pharmaceutical Services shares the industry events it will attend in 2024

The aseptic manufacturing specialists will have an exhibiting presence at an additional 5 events globally this year

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CPTx is pioneering in vivo production of precision genetic medicines using single-stranded DNA.
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