Spray chilling now available in the lab

Published: 1-Sep-2005
Sustainability


A new system from Swiss instrument supplier Buechi Labortechnik has provided companies with a way to carry out spray chilling tests in the lab when looking to optimise drug application. Buechi has extended its Mini Spray Dryer B-290 in a way that enables spray chilling to easily be performed on a small scale.

Spray drying is widely established as a method of producing microcapsules or particles, and spray chilling - also called spray congealing - is a newer but similar method. With spray chilling, a melting is dispersed into a cold gas stream leading to solidification of the droplets into particles that can be separated. Typical carriers are fatty acids or alcohols, waxes, stearates or PEGs.

Until now, the development of spray congealing methods was possible only from pilot plant-scale and upwards. This new system from Buechi means it is now possible to carry out laboratory-scale tests.

The new equipment consists of a thermo regulated feed vessel, a heater with control and a feed valve. An additional external thermostat is not required. The temperature range of the melting is between 30° and 70°C. At low melting points, an additional air pre-cooler is required which cools the inlet air down to -5°C for a quick and efficient solidification of the droplets.

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