Symbiosis Pharmaceutical Services Ltd (Symbiosis), a fast-growing contract manufacturing organisation (CMO) specialising in sterile global manufacture of pharmaceuticals, vaccines and biopharmaceuticals including Advanced Therapeutical Medicinal Products (ATMPs), has announced the completion of a £1.3 million collaborative UKRI-funded project as part of the medicines manufacturing challenge.
Symbiosis and The Cell and Gene Therapy Catapult (CGT Catapult) have successfully developed and demonstrated a lean manufacturing supply chain in partnership with Freeline Therapeutics for the sterile filling and manufacturing process of drug product.
The project learnings will now accelerate the manufacturing supply chain for ATMPs within the UK.
John McCormick, COO of Symbiosis said: “The results are very positive.
“The aim of the project was to reduce the production cycle by up to 25%. Shortening timelines reduces storage costs and can increase manufacturing facility utilisation. For many drug development projects, reducing manufacturing timelines, even by a few days, can facilitate these life changing medicines entering the clinic sooner.
“Initiation of drug product manufacture and processing at Symbiosis for the Freeline viral vector was able to start approximately four weeks from completion of drug substance manufacture and release testing at the CGT Catapult in Stevenage, UK. This compares to typical post-release testing timelines of up to 12 weeks; representing a reduction in the timeline of over 60%.
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