Waterless foam offers enhanced skin delivery

Israeli company Foamix has developed a novel waterless foam vehicle for the delivery of water insoluble and water-sensitive dermatological drugs.

The main components of the carrier are propylene glycol, glycerin and additional polar solvents, which are known to enhance the delivery of active agents into the skin, while providing a high skin hydration effect.

Foamix chose specific, delicate, FDA-approved non-ionic surfactants and polymers to create the foaming action. A series of accelerated stability studies, encompassing a broad spectrum of corticosteroids as well as non-steroidal active agents, has revealed good stability in all cases.

"This formulation produces a stable foam when re-leased from a pressurised aerosol can, is easily applied with gentle spreading and is instantly absorbed into the skin," said Foamix chief technical officer Dr Doron Friedman. "It leaves neither a sticky nor a greasy feeling nor any shine, unlike conventional creams and ointments."

The company is utilising this proprietary waterless and alcohol-free foam platform to develop a broad spectrum of topical drugs, including steroids, antibiotics, antifungals, antivirals and a hair growth drug.