In line with its sustainability ethics, Alpha Laboratories is delighted to introduce the new PYROSTAR Neo+ from FUJIFILM Wako. This endotoxin detection reagent has been developed by recombinant technology to provide a synthetic LAL assay alternative, designed with wildlife conservation in mind. This innovative product offers a non-animal derived solution for bacterial endotoxin testing (BET) in research, pharmaceutical, and medical equipment manufacturing. By replacing conventional LAL reagents sourced from Atlantic Horseshoe Crabs, PYROSTAR Neo+ helps reduce the impact on wildlife, while facilitating the same high sensitivity as PYROSTAR ES-F.
PYROSTAR Neo+ utilises a recombinant 3 Factor system that replicates the equivalent cascade reaction of traditional LAL assays. It boasts improved specificity with the absence of Factor G, and eliminates interference due to reaction with β-glucan. Additionally, it has an optimised formulation to support handling of difficult sample matrices which cause interference.
The Neo+ reagent contains a pNA chromogenic group, enabling detection of the assay results on an absorbance plate reader using a colorimetric method recombinant cascade reagent (rCR) assay. The endotoxin test offers clear ethical and environmental advantages over the traditional LAL test, including its compliance with the 3Rs principles of replacement, reduction, and refinement of animal testing.
