Certa Therapeutics, a biotechnology company developing innovative precision therapies for patients with fibrotic diseases, announces the acquisition of OccuRx, a Melbourne-based biotechnology company with highly complementary assets, resources and expertise, and a shared focus on targeting GPR68, a master switch of fibrosis.
The acquisition combines the assets and capabilities of two companies founded by a leader in the GPR68 field, Professor Darren Kelly, consolidating a pipeline that now includes two Phase II and one Phase I clinical candidates.
Building on Professor Kelly’s pioneering research into inhibitors of GPR68 and benefiting from years of further development within biotechnology and major pharma companies, Certa’s pipeline aims to tackle fibrotic diseases upstream of other targeted biological pathways.
Certa’s lead programme is asengeprast (FT011) a novel, first-in-class oral therapy for the treatment of chronic fibrosis in multiple organs, which has shown favourable efficacy, safety and pharmacokinetics in patients with systemic sclerosis (scleroderma or SSc).
Post the acquisition, Certa’s pipeline will include the additional asset OCX063 from OccuRx which has successfully completed a Phase I clinical trial and is in development for focal segmental glomerulosclerosis (FSGS), a rare disease characterised by fibrosis developing in the kidney glomerulus.
In addition, Certa also has CTA382, a second-generation compound with the same chemical backbone as Asengeprast, that is under development to treat chronic kidney disease and a third-generation series of preclinical GPR68 antagonists, based on a different chemical backbone.
Assets from this series are being developed for other fibrotic conditions and wider therapeutic indications.
Professor Darren Kelly, Certa Therapeutics’ CEO and founder, said: “Fibrotic diseases are an area of significant unmet need."
"We believe GPR68 is a critical master switch of fibrosis and through this acquisition we have brought together a unique pipeline and a passionate, experienced team that’s uniquely equipped to drive its development. We look forward to rapidly advancing our programmes and, ultimately, developing new safe, effective precision therapies for patients.”
Dr Chris Nave, chair of Certa Therapeutics and Managing Partner of lead investor Brandon Capital, added: "Bringing together the assets and expertise of Certa Therapeutics and OccuRx under one company creates a powerful platform to advance transformative therapies for fibrotic diseases."
"This consolidation reinforces Certa’s leadership in the GPR68 field and its commitment to developing innovative treatments with a promising clinical-stage pipeline of GPR68 antagonists.”