Filter for kinase assay performance launched

Published: 1-Nov-2004


US company Millipore has launched its MultiScreenHTS-PH filter plates for high throughput kinase screening assays. The 96-well filter plates are automation compatible and follow a prevalidated protocol for high sensitivity, high specificity and reliable kinase assay screening.

The plates incorporate PH paper for optimised kinase assay performance. PH paper retains peptide substrates to remove the unreacted, labelled ATP (Adenosine Triphosphate), and provides lower background and improved discrimination between drug target hits and non-hits. In addition, the paper is not subject to naturally fluorescent or quenching compounds, making it compatible with aromatic-based libraries. Kinase assays are a critical step in both lead identification and later lead characterisation processes.

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